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| 产品编号 | KMH366 |
|---|---|
| 产品名称 | Recombinant Human CD202B/TEK Protein, His Tag |
| 产品描述 | Recombinant Human CD202B/TEK Protein, His Tag (KMH366) contains the human TEK(Met1-Lys745) was fused with the C-terminal His Tag and expressed in Mammalian cells. |
| 分子名称 | TEK |
| 产品别称 | TIE2, VMCM, GLC3E, TIE 2, VMCM1, CD202B, TEK receptor tyrosine kinase |
| 规格 | 50ug, 100ug |
| 物种 | Human |
| 宿主 | Mammalian cells |
| 蛋白家族 | CD molecule |
| 编录号 | Q02763 |
| 纯度 | ≥90% as determined by SDS-PAGE |
| 内毒素水平 | < 1.0 EU per ug of the protein as determined by the LAL method. |
| 缓冲体系 | PBS |
| 分子量 | 81.95 kDa |
| 纯化方式 | Affinity Purification |
| 产品背景 | The molecularweight of the dimer is 25 kDa. The soluble receptor protein consists of thefull extracellular domain (Met1-Val73). TIE-1 (tyrosine kinase with Ig andEGF homology domains 1) and TIE2/TEK comprise a receptor tyrosine kinase(RTK) subfamily with unique structural characteristics: twoimmunoglobulin-like domains flanking three epidermal growth factor (EGF)-likedomains and followed by three fibronectin type III-like repeats in theextracellular region and a split tyrosine kinase domain in the cytoplasmicregion. These receptors are expressed primarily on endothelial andhematopoietic progenitor cells and play critical roles in angiogenesis,vasculogenesis and hematopoiesis. Human TIE2 cDNA encodes a 1124 amino acidresidue precursor protein with an 18 residue putative signal peptide, a 727residue extracellular domain and a 354 residue cytoplasmic domain. Twoligands, angiopoietin 1 and angiopoietin 2, which bind TIE2 withhigh-affinity have been identified. |
| 保存条件 | Store the product under sterile conditions after opening at -20℃ to -80℃ for 12 months. Avoid repeated freeze-thaw cycles. |
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