卡梅德生物科技（天津）有限公司
400-621-6806
服务电话：400-621-6806
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| 产品编号 | KMH517 |
|---|---|
| 产品名称 | Recombinant Human IDO/IDO1 Protein, His Tag |
| 产品描述 | Recombinant Human IDO/IDO1 Protein, His Tag (KMH517) contains the human IDO1(Ala2-Gly403) was fused with the N-terminal His Tag and expressed in E. coli. |
| 分子名称 | IDO1 |
| 产品别称 | IDO, INDO, IDO 1, indoleamine 2,3 dioxygenase 1 |
| 规格 | 50ug, 100ug |
| 物种 | Human |
| 宿主 | E. coli |
| 蛋白家族 | Immune checkpoint |
| 编录号 | P14902 |
| 纯度 | ≥90% as determined by SDS-PAGE |
| 内毒素水平 | Please contact our customer service for more information. |
| 缓冲体系 | PBS |
| 分子量 | 44.33 kDa |
| 纯化方式 | Affinity Purification |
| 产品背景 | Indoleamine 2,3-dioxygenase(IDO) is a hemecontaining intracellular dioxygenase catalyzing the degradation of the essential amino acid L-tryptophan toN-formylkynurenine. This degradation is the first and ratelimiting step of the L-kynurenine pathway. IDO is widely expressed in dendritic cells, macrophages,microglia, eosinophils, fibroblasts, endothelial cells, and most tumor cells. In immune cells, its expression is mainly induced by cytokines such as IFN-γ, IFN-α,IFN-β, and IL-1. IDO has an antimicrobial function due to its decreasing the availability of the essential amino acid tryptophan in inflammatory environments.Recent studies have demonstrated that IDO induces immunosuppression during infection, pregnancy, transplantation, autoimmunity, and neoplasia. |
| 保存条件 | Store the product under sterile conditions after opening at -20℃ to -80℃ for 12 months. Avoid repeated freeze-thaw cycles. |
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