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| 产品编号 | KMP2709 |
|---|---|
| 产品名称 | Human CD86 Protein, His Tag |
| 产品描述 | The Human CD86 Protein(KMP2709) is produced in HEK293 Cells. The target gene encoding the extracellular domain (Met1-His239) of human B7-2 (NP_008820.2) is fused with a polyhistidine tag at the C-terminus. The purified protein is biotinylated in vitro. |
| 分子名称 | CD86 |
| 产品别称 | 重组白细胞分化抗原86, Human CD86 Protein, His Tag, CD86 |
| 物种 | Human |
| 宿主 | HEK293 Cells |
| 规格 | 50ug, 100ug, 200ug |
| 纯度 | >95% as determined by SDS-PAGE |
| 纯化方式 | Affinity purification |
| 内毒素水平 | <1.0 EU/ug determined by the LAL method |
| 缓冲体系 | PBS |
| 产品背景 | CD86, also known as B-lymphocyte activation antigen B7-2 (referred to as B70), is a member of the cell surface immunoglobulin superfamily. B7-2 exists predominantly as a monomer on cell surfaces and interacts with two co-stimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on T cells, and thus induces the signal pathways which regulate T cell activation and tolerance, cytokine production, and the generation of CTL. It is indicated that contacts between B and T helper cells mediated by CD86 encourage signals for the proliferation and IgG secretion of normal B cells and B cell lymphomas. A recent study has revealed that CD86 also promotes the generation of a mature APC repertoire and promotes APC function and survival. CD86 has an important role in chronic hemodialysis, allergic pulmonary inflammation, arthritis, and antiviral responses, and thus is regarded as a promising candidate for immune therapy. |
| 保存条件 | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| 说明 | This product is for research use only. |
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