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| 产品编号 | KMP2733 |
|---|---|
| 产品名称 | Human CD70 Protein, hFc Tag |
| 产品描述 | The Human CD70 Protein(KMP2733) is produced in HEK293 Cells. The target gene encoding the extracellular domain of human CD70 (NP_001243.1) (Gln 39-Pro 193) is fused with the Fc region of human IgG1 at the N-terminus via a polypeptide linker. |
| 分子名称 | CD70 |
| 产品别称 | 肿瘤坏死因子配体超家族成员 7, Human CD70 Protein, hFc Tag, CD70 |
| 物种 | Human |
| 宿主 | HEK293 Cells |
| 规格 | 50ug, 100ug, 200ug |
| 纯度 | >90% as determined by SDS-PAGE |
| 纯化方式 | Affinity purification |
| 内毒素水平 | <1.0 EU/ug determined by the LAL method |
| 缓冲体系 | PBS, pH7.4 |
| 产品背景 | CD70, a member of the tumor necrosis factor superfamily, is restricted to activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its receptor, CD27, is important in priming, effector functions, differentiation and memory formation of T-cells as well as plasma and memory B-cell generation. Tight control of CD70 expression is required to prevent lethal immunodeficiency. By selective transcription, CD70 is largely confined to activated lymphocytes and dendritic cells (DC). As a type II transmembrane receptor, CD70 is normally expressed on a subset of B, T and NK cells, where it plays a costimulatory role in immune cell activation. Immunohistochemical analysis of CD70 expression in multiple carcinoma types. The restricted expression pattern of CD70 in normal tissues and its widespread expression in various malignancies makes it an attractive target for antibody-based therapeutics. Investigations to exploit CD70 as a cancer target have lead to the identification of potential antibody-based clinical candidates. |
| 保存条件 | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| 说明 | This product is for research use only. |
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