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| 产品编号 | KMP2744 |
|---|---|
| 产品名称 | Human FLT4 Protein, His Tag, Avi Tag |
| 产品描述 | The Human FLT4 Protein(KMP2744) is produced in HEK293 Cells. The target gene encoding the human VEGFR3/FLT4 (NP_002011.2) (Met1-Ile776) is expressed with a C-terminal Avi tag followed by a His tag. The expressed protein is biotinylated in vivo by the Biotin-Protein ligase (BirA enzyme) which is co-expressed. |
| 分子名称 | FLT4 |
| 产品别称 | 血管内皮生长因子受体3, Human FLT4 Protein, His Tag, Avi Tag, FLT4 |
| 物种 | Human |
| 宿主 | HEK293 Cells |
| 规格 | 50ug, 100ug, 200ug |
| 纯度 | >95% as determined by SDS-PAGE |
| 纯化方式 | Affinity purification |
| 内毒素水平 | <1.0 EU/ug determined by the LAL method |
| 缓冲体系 | PBS, pH7.4 |
| 产品背景 | Vascular endothelial growth factor receptor 3 (VEGFR3), also known as FLT-4, together with the other two members VEGFR1 (FLT-1) and VEGFR2 (KDR/Flk-1) are receptors for vascular endothelial growth factors (VEGF) and belong to the class III subfamily of receptor tyrosine kinases (RTKs). The VEGFR3 protein is expressed mainly on lymphatic vessels but it is also up-regulated in tumor angiogenesis. Mutations in VEGFR3 have been identified in patients with primary lymphoedema. The VEGF-C/VEGF-D/VEGFR3 signaling pathway may provide a target for antilymphangiogenic therapy in prostate cancer, breast cancer, gastric cancer, lung cancer, non-small cell lung cancer (NSCLC), and so on. |
| 保存条件 | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| 说明 | This product is for research use only. |
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