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| 产品编号 | KMP3573 |
|---|---|
| 产品名称 | Human IL-6 Protein |
| 产品描述 | The Human IL-6 Protein(KMP3573) is produced in E. coli. The target gene encoding the mature form of human IL6 (NP_000591.1) (Val30-Met212) is expressed with an initial Met at the N-terminus. |
| 分子名称 | IL-6 |
| 产品别称 | 白介素6, Human IL-6 Protein, IL-6 |
| 物种 | Human |
| 宿主 | E. coli |
| 规格 | 50ug, 100ug, 200ug |
| 纯度 | >95% as determined by SDS-PAGE |
| 纯化方式 | Affinity purification |
| 内毒素水平 | <5.0 EU/mg determined by the LAL method |
| 缓冲体系 | PBS, pH7.4 |
| 产品背景 | Interleukin-6 (IL-6) is a multifunctional α-helical cytokine that regulates cell growth and differentiation of various tissues, which is known particularly for its role in the immune response and acute phase reactions. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as a phosphorylated and variably glycosylated molecule. It exerts actions through its heterodimeric receptor composed of IL-6R that lacks the tyrosine/kinase domain and binds IL-6 with low affinity, and ubiquitously expressed glycoprotein 130 (gp130) that binds the IL-6. IL-6R complex with high affinity and thus transduces signals. IL-6 is also involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined as an essential role in directing the transition from innate to acquired immunity. |
| 保存条件 | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| 说明 | This product is for research use only. |
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