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| 产品编号 | KMP4260 |
|---|---|
| 产品名称 | Rat CTLA-4 Protein, hFc Tag |
| 产品描述 | The Rat CTLA-4 Protein(KMP4260) is produced in HEK293 Cells. A DNA sequence encoding the rat Ctla4 (NP_113862.1) (Met1-Asp161) is expressed with the Fc region of human IgG1 at the C-terminus. |
| 分子名称 | CTLA-4 |
| 物种 | Rat |
| 宿主 | HEK293 Cells |
| 规格 | 50ug, 100ug, 200ug |
| 纯度 | >95% as determined by SDS-PAGE |
| 纯化方式 | Affinity purification |
| 内毒素水平 | <1.0 EU/ug determined by the LAL method |
| 缓冲体系 | PBS, pH7.4 |
| 产品背景 | Cytotoxic T-lymphocyte protein 4, also known as CTLA4 and CD152, is a single-pass type I membrane protein and a member of the immunoglobulin superfamily. It is the second member of the CD28 receptor family. The ligands or counterreceptors for these two proteins are the B7 family members, CD80 (B7-1) and CD86 (B7-2). CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may play an important role in their functions. CD152 or cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential receptor involved in the negative regulation of T cell activation. Because of its profound inhibitory role, CD152 has been considered a sound susceptible candidate in autoimmunity and a persuasive target for cancer immunotherapy. In particular, recent evidence suggests that CD152 is also important in the homeostasis and function of a population of suppressive cells, termed regulatory T cells (Treg). |
| 保存条件 | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| 说明 | This product is for research use only. |
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