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| 产品编号 | KMP4353 |
|---|---|
| 产品名称 | Rhesus EpCAM Protein, hFc Tag |
| 产品描述 | The Rhesus EpCAM Protein(KMP4353) is produced in HEK293 Cells. A DNA sequence encoding the Cynomolgus/Rhesus EPCAM [(Identical to the Rhesus EPCAM (NP_001035118.1)] (Met1-Lys265) is expressed with the Fc region of human IgG1 at the C-terminus. Cynomolgus and Rhesus EPCAM sequences are identical. |
| 分子名称 | EpCAM |
| 物种 | Rhesus |
| 宿主 | HEK293 Cells |
| 规格 | 50ug, 100ug, 200ug |
| 纯度 | >95% as determined by SDS-PAGE |
| 纯化方式 | Affinity purification |
| 内毒素水平 | <1.0 EU/ug determined by the LAL method |
| 缓冲体系 | PBS, pH7.4 |
| 产品背景 | Epithelial Cell Adhesion Molecule (EpCAM), also known as GA733-2 antigen, is a type I transmembrane glycoprotein composed of an extracellular domain with two EGF-Like repeats and a cystenin-rich region, a transmembrane domain and a cytoplasmic domain. It modulates cell adhesion and proliferation. Its overexpression has been detected in many epithelial tumours and has been associated with high stage, high grade and a worse survival in some tumour types. EpCAM has been shown to function as a calcium-independent homophilic cell adhesion molecule that does not exhibit any obvious relationship to the four known cell adhesion molecule superfamilies. However, recent insights have revealed that EpCAM participates in not only cell adhesion, but also in proliferation, migration and differentiation of cells. In addition, recent study revealed that EpCAM is the Wnt-beta-catenin signaling target gene and may be used to facilitate prognosis. It has oncogenic potential and is activated by release of its intracellular domain, which can signal into the cell nucleus by engagement of elements of the wnt pathway. |
| 保存条件 | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| 说明 | This product is for research use only. |
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