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| 产品编号 | MOP2075 |
|---|---|
| 产品名称 | Recombinant Mouse B7-h2/Icoslg/CD275/Icosl Protein, His Tag |
| 产品描述 | Recombinant Mouse B7-h2/Icoslg/CD275/Icosl Protein, His Tag (MOP2075) contains the mouse Icoslg(Glu47-Lys279) was fused with the C-terminal His Tag and expressed in Mammalian cells. |
| 分子名称 | Icosl |
| 产品别称 | B7h, GI50, GL50, B7 H2, LICOS, B7RP 1, GL50 B, ICOS L, Icoslg, Ly115l, AU044799, BG071784, mKIAA0653, icos ligand |
| 规格 | 50ug, 100ug |
| 物种 | Mouse |
| 宿主 | Mammalian cells |
| 蛋白家族 | Other protein |
| 编录号 | Q9JHJ8 |
| 纯度 | ≥90% as determined by SDS-PAGE |
| 内毒素水平 | < 1.0 EU per ug of the protein as determined by the LAL method. |
| 缓冲体系 | PBS |
| 分子量 | 25.63 kDa |
| 纯化方式 | Affinity Purification |
| 产品背景 | Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains, and binds to ICOS on activated T cells, thus delivers a positive costimulatory signal for optimal T cell function. The structural features of ICOSL are crucial for its costimulatory function. Present study shows that ICOSL displays a marked oligomerization potential, resembling more like B7-1 than B7-2. ICOSL constructs lacking either the IgC or IgV domain demonstrates that receptor binding is mediated solely by the IgV domain but requires the IgC domain for maintaining the structural integrity of the protein. |
| 保存条件 | Store the product under sterile conditions after opening at -20℃ to -80℃ for 12 months. Avoid repeated freeze-thaw cycles. |
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